With obesity affecting over one billion people worldwide, patient-centric clinical trial design is essential to improve recruitment, engagement, and retention. IQVIA highlights how incorporating patient insights, advisory boards, and targeted outreach can address barriers such as stigma, financial concerns, treatment fatigue, and mistrust. Sponsors can improve participation by creating supportive trial experiences through flexible scheduling, virtual visits, personalized nutrition guidance, motivational messaging, and staff training focused on empathy. Tailored communication, local site intelligence, and digital engagement further enhance inclusivity and retention. By placing patients' lived experiences at the center of trial design, sponsors can build more effective, engaging, and success

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