The Excel Problem explores the risks of relying on spreadsheets for product and process data management in the life sciences industry. While Excel is widely used because it is accessible, familiar, and easy to use, it was not designed to manage the complex, regulated, and data-intensive workflows required in pharmaceutical and biopharmaceutical development and manufacturing. Excessive dependence on spreadsheets can lead to data silos, version control issues, manual errors, limited traceability, and compliance risks, particularly in highly regulated environments. The report argues that while Excel remains useful for ad hoc analysis and calculations, organizations should adopt specialized data management platforms for critical product and process information. Solutions such as Skyland PIMS p

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