This paper explores practical and responsible applications of AI within Medical Affairs. It highlights use cases such as literature review automation, AI-assisted chart review, real-world data consolidation, KOL identification, and scientific communications enhancement. Emphasis is placed on governance, reliability, regulatory compliance, and the need for human oversight. The report outlines requirements for enterprise AI adoption, including trust-building, tool selection, and continuous monitoring. By adopting defensible AI strategies, Medical Affairs teams can increase efficiency, improve insight generation, and deliver measurable value to patients and stakeholders.

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