This paper provides a structured approach to estimating market opportunity in the medical devices and diagnostics sector, where traditional pharmaceutical models often fall short. It explains key concepts such as total addressable, serviceable, and obtainable markets, while highlighting challenges like fragmented data, adoption variability, and reimbursement complexity. The report outlines a blended top-down and bottom-up methodology incorporating epidemiology, procedure volumes, pricing, and adoption curves. Through case examples, it demonstrates how rigorous market sizing supports strategic planning, investment decisions, and commercialization strategies in both established and emerging MedTech markets.

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