The SANS 2022 Ransomware Defense Report analyzes how ransomware evolved in 2020–2021, with threats rising due to remote work and RaaS. Adversaries study targets, weaponize vulnerabilities fast, use fileless malware, and automate attacks to act within hours. Defenders are encouraged to adopt in-memory analysis, behavioral detection, automation, and layered defense strategies. Case studies highlight risks from remote access and native binaries. New approaches like Encrypted Traffic Analysis and Moving Target Defense offer promise. The report urges customized, proactive defenses to outpace modern ransomware tactics.

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