This insight brief examines how the widespread adoption of pre-exposure prophylaxis (PrEP) has reshaped the HIV landscape. While PrEP has significantly reduced new infections in certain populations, disparities in access, adherence, and awareness persist. The brief analyzes evolving epidemiology, shifting prevention behaviors, and remaining unmet needs. It highlights opportunities to improve outcomes through better data integration, targeted engagement, and expanded prevention strategies. IQVIA emphasizes the importance of combining clinical innovation, real-world data, and public health collaboration to sustain progress toward HIV prevention goals.

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