This paper addresses the growing global burden of non-communicable diseases (NCDs), which account for 75% of deaths worldwide. It highlights a critical gap: despite strong evidence supporting early intervention, health systems remain focused on reactive, late-stage care. The report identifies structural barriers such as misaligned resource allocation, fragmented care delivery and persistent inequalities. It introduces a comprehensive framework for transformation across prevention, governance, financing, workforce development, medicines and environmental sustainability. Central to the report is the need for integrated, system-wide action that addresses root causes and prioritizes equity. It emphasizes that improving outcomes requires not just new policies but coordinated implementation and

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